PSC Partners Seeking a Cure is a 501(c)3 nonprofit foundation that endeavors to find a cure for Primary Sclerosing Cholangitis. Today this liver disease has no specific treatment. PSC is affecting the lives of too many people including young children, college students, mothers, fathers, and grandparents. With no treatment or cure, people with this disease are suffering and dying while awaiting the uncertainty of a liver transplant. Little is known about this disease and its course is hard to predict. What isn't hard to predict is the heart break the next family will experience when PSC strikes them. Patients and caregivers need support and information. We desperately need research for treatment and a cure for PSC now. Please consider a donation to help us conquer this devastating disease.

The three-fold purpose of the PSC Partners Seeking a Cure foundation is to:

(i) raise funds with which to research the causes and cures of PSC,
(ii) provide education and support to PSC patients and their families, and
(iii) promote PSC and organ donation awareness.

PSC: Treatment & Search for a Cure
A public forum for Primary Sclerosing Cholangitis Patients & Caregivers
Tuesday September 8, 2009 6-9 pm
The Mount Sinai Hospital, Hatch Auditorium
1160 Fifth Ave at 100th Street, Second floor Guggenheim Pavilion

The 6th PSC Partners Seeking a Cure conference will be held May 14 -16, 2010 in Hartford, Connecticut in conjunction with Yale University.

PROGRESS (PSC Resource Of Genetic Risk, Environment and Synergy Studies). If you are a PSC patient interested in participating in this Mayo Clinic study, please visit the link above to find details of the clinical trial and contact information.

Announcement Concerning An Oral Vancomycin Trial for Adult PSC Patients in the Boston, MA Area [.pdf]

If you are a PSC researcher seeking grant support, please consult the PSC Partners Seeking a Cure: Request for Proposals. If you are a PSC patient or caregiver, please consider joining our mailing list:

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PSC Partners Seeking a Cure has recently donated $40,000 to support the STOPSC research initiative of the Morgan Foundation; see press release from: Memphis Business News, Jan 8, 2007.

PSC Partners Seeking a Cure awards a $3,000 prize annually at the annual meeting of the American Association for the Study of Liver Diseases (AASLD). The recipient of the 2007 PSC Partners Seeking a Cure AASLD Award was Dr. Thomas H. Karlsen (Medical Department and Institute of Immunology, Rikshospitalet-Radiumhospitalet Medical Center, Oslo, Norway), as described in the AASLD 2007 Annual Report. The recipients of the 2008 PSC Partners Seeking a Cure AASLD Awards were Dr. I. Tornai (2nd Department of Medicine, University of Debrecen, Debrecen, Hungary), and Dr. P. G. Blanco (Beth Israel Deaconess Medical Center, Boston, MA, USA), as described in the AASLD 2008 Annual Report.

In its recent January 2009 grants competition, PSC Partners Seeking a Cure made 3 awards of $40,000 each to the following investigators and projects:

• Konstantinos N. Lazaridis, M.D., Assistant Professor of Medicine, Center for Basic Research in Digestive Disease, Mayo Clinic College of Medicine 200 First Street SW, Rochester, MN 55905. Examining the Disease Impact of Genetic Variation in Logical Candidate Genes for PSC: a PROGRESS Study. 
• Pietro Invernizzi, MD, Ph.D, Assistant Professor of Medicine, Division of Rheumatology, Allergy, and Clinical Immunology, University of California, Davis GBSF suite 6515, Davis, CA 95616. Cholangiocarcinoma-associated serum microRNAs in primary sclerosing cholangitis: Identification and prognostic potential. 
• Cyriel Y. Ponsioen, MD, PhD, Department of Gastroenterology & Hepatology, Academic Medical Center, C2-112, P.O. Box 22700, 1100 DE Amsterdam, The Netherlands. Aberrant homing of lymphocytes to the liver in patients with primary sclerosing cholangitis; the missing link between colon and liver. 

Congratulations to Drs. Lazaridis, Invernizzi, and Ponsioen! For further details of these awards, please see: Research Awards (2009). In total, PSC Partners Seeking a Cure has invested $169,000 in PSC research.

For more information about PSC, please see our brochures, "Living with Primary Sclerosing Cholangitis (PSC)" and "Diagnosing PSC" (both in portable document format (.pdf); you will need the free Adobe Acrobat Reader installed on your computer to read these files). To order printed copies of the Living with Primary Sclerosing Cholangitis (PSC) brochure, and/or the Diagnosing PSC brochure, please send an e-mail with your name, mailing address and desired quantity, to Barb Henshaw at: brochures@pscpartners.org. If requesting more then 50 brochures, please let us know how you plan to distribute them. Please allow 1-2 weeks for delivery.

The Living with Primary Sclerosing Cholangitis brochure is also available in Hebrew "Living with Primary Sclerosing Cholangitis (PSC); Hebrew Translation", thanks to Ellen and Chaim Boermeester of Israel.